p27(Kip1) Directly Represses Sox2 during Embryonic Stem Cell Differentiation

The mechanisms responsible for the transcriptional silencing of pluripotency genes in differentiated cells are poorly understood. We have observed that cells lacking the tumor suppressor p27 can be reprogrammed into induced pluripotent stem cells (iPSCs) in the absence of ectopic Sox2. Interestingly...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Li, Han, Collado, Manuel, Villasante, Aranzazu, Matheu, Ander, Lynch, Cian J., Cañamero, Marta, Rizzoti, Karine, Carneiro, Carmen, Martínez, Gloria, Vidal, Anxo, Lovell-Badge, Robin, Serrano, Manuel
Format: Artigo
Langue:Inglês
Publié: Cell Press 2012
Sujets:
Short Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549496/
https://ncbi.nlm.nih.gov/pubmed/23217425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.09.014
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