p27(Kip1) Directly Represses Sox2 during Embryonic Stem Cell Differentiation

The mechanisms responsible for the transcriptional silencing of pluripotency genes in differentiated cells are poorly understood. We have observed that cells lacking the tumor suppressor p27 can be reprogrammed into induced pluripotent stem cells (iPSCs) in the absence of ectopic Sox2. Interestingly...

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Autori principali: Li, Han, Collado, Manuel, Villasante, Aranzazu, Matheu, Ander, Lynch, Cian J., Cañamero, Marta, Rizzoti, Karine, Carneiro, Carmen, Martínez, Gloria, Vidal, Anxo, Lovell-Badge, Robin, Serrano, Manuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2012
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Short Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549496/
https://ncbi.nlm.nih.gov/pubmed/23217425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.09.014
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