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c-Src Activation Mediates Erlotinib Resistance in Head and Neck Cancer by Stimulating c-Met

PURPOSE: Strategies to inhibit the epidermal growth factor receptor (EGFR) using the tyrosine kinase inhibitor (TKI) erlotinib have been associated with limited clinical efficacy in head and neck squamous cell carcinoma (HNSCC). Co-activation of alternative kinases may contribute to erlotinib resist...

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Bibliografiske detaljer
Main Authors: Stabile, Laura P., He, Guoqing, Lui, Vivian Wai Yan, Henry, Cassandra, Gubish, Christopher T., Joyce, Sonali, Quesnelle, Kelly, Siegfried, Jill M., Grandis, Jennifer R.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549019/
https://ncbi.nlm.nih.gov/pubmed/23213056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1555
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