Histone deacetylase inhibitor AR-42 differentially affects cell cycle transit in meningeal and meningioma cells, potently inhibiting NF2-deficient meningioma growth

Meningiomas constitute ~34% of primary intracranial tumors and are associated with increased mortality in NF2 patients. To evaluate potential medical therapies for these tumors, we have established a quantifiable orthotopic model for NF2-deficient meningiomas. We showed that telomerase-immortalized...

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Autori principali: Burns, Sarah S., Akhmametyeva, Elena M., Oblinger, Janet L., Bush, Matthew L., Huang, Jie, Senner, Volker, Chen, Ching-Shih, Jacob, Abraham, Welling, D. Bradley, Chang, Long-Sheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549000/
https://ncbi.nlm.nih.gov/pubmed/23151902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1888
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