Activities, crystal structures and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase

Based on a series of lactam and phthalimide derivatives that inhibit HIV-1 integrase, we developed a new derivative, XZ-259, with biochemical and antiviral activities comparable to raltegravir. We determined the crystal structures of XZ-259 and four other derivatives in complex with the prototype fo...

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Detalhes bibliográficos
Main Authors: Métifiot, Mathieu, Maddali, Kasthuraiah, Johnson, Barry C., Hare, Stephen, Smith, Steven J., Zhao, XueZhi, Marchand, Christophe, Burke, Terrence R., Hughes, Stephen H., Cherepanov, Peter, Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548936/
https://ncbi.nlm.nih.gov/pubmed/23075516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300471n
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