De Novo Design of a Tumor-Penetrating Peptide

Poor penetration of anti-tumor drugs into the extravascular tumor tissue isoften a major factor limiting the efficacy of cancer treatments. Our group has recently described a strategy to enhance tumor penetration of chemotherapeutic drugs through use of iRGD peptide (CRGDK/RGPDC). This peptide compr...

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Bibliografiske detaljer
Main Authors: Alberici, Luca, Roth, Lise, Sugahara, Kazuki N., Agemy, Lilach, Kotamraju, Venkata R., Teesalu, Tambet, Bordignon, Claudio, Traversari, Catia, Rizzardi, Gian-Paolo, Ruoslahti, Erkki
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548935/
https://ncbi.nlm.nih.gov/pubmed/23151901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1668
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