Tissue-penetrating delivery of compounds and nanoparticles into tumors

Poor penetration of drugs into tumors is a major obstacle in tumor treatment. We describe a strategy for peptide-mediated delivery of compounds deep into the tumor parenchyma that employs a tumor homing peptide, iRGD (CRGDK/RGPD/EC). Intravenously injected compounds coupled to iRGD bound to tumor ve...

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Detalhes bibliográficos
Main Authors: Sugahara, Kazuki N., Teesalu, Tambet, Karmali, Priya Prakash, Kotamraju, Venkata Ramana, Agemy, Lilach, Girard, Olivier M., Hanahan, Douglas, Mattrey, Robert F., Ruoslahti, Erkki
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791543/
https://ncbi.nlm.nih.gov/pubmed/19962669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.10.013
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