Src Phosphorylation of Endothelial Cell Surface ICAM-1 Mediates Neutrophil Adhesion and Contributes to the Mechanism of Lung Inflammation

OBJECTIVE: To determine whether TNFα-induced Src activation and ICAM-1 phosphorylation rapidly increases endothelial cell adhesivity and PMN sequestration independent of de novo ICAM-1 synthesis. METHODS AND RESULTS: TNFα exposure of mouse lungs for 5 min produced a 3-fold increase in (125)I-anti-IC...

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Bibliographic Details
Main Authors: Liu, Guoquan, Vogel, Stephen M., Gao, Xiaopei, Javaid, Kamran, Hu, Guochang, Danilov, Sergei M., Malik, Asrar B., Minshall, Richard D.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548602/
https://ncbi.nlm.nih.gov/pubmed/21474822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.222208
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