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Src Phosphorylation of Endothelial Cell Surface ICAM-1 Mediates Neutrophil Adhesion and Contributes to the Mechanism of Lung Inflammation
OBJECTIVE: To determine whether TNFα-induced Src activation and ICAM-1 phosphorylation rapidly increases endothelial cell adhesivity and PMN sequestration independent of de novo ICAM-1 synthesis. METHODS AND RESULTS: TNFα exposure of mouse lungs for 5 min produced a 3-fold increase in (125)I-anti-IC...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3548602/ https://ncbi.nlm.nih.gov/pubmed/21474822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.222208 |
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