Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells

Introduction. Overexpression of the Polycomb repressive complex 2 (PRC2) subunit Enhancer of Zeste 2 (EZH2) occurs in several malignancies, including prostate cancer, breast cancer, medulloblastoma, and glioblastoma multiforme. Recent evidence suggests that EZH2 may also have a role in rhabdoid tumo...

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Main Authors: Alimova, Irina, Birks, Diane K., Harris, Peter S., Knipstein, Jeffrey A., Venkataraman, Sujatha, Marquez, Victor E., Foreman,, Nicholas K., Vibhakar, Rajeev
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Basic and Translational Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548579/
https://ncbi.nlm.nih.gov/pubmed/23190500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos285
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