Human Indoleamine 2,3-Dioxygenase Is a Catalyst of Physiological Heme Peroxidase Reactions: IMPLICATIONS FOR THE INHIBITION OF DIOXYGENASE ACTIVITY BY HYDROGEN PEROXIDE

The heme enzyme indoleamine 2,3-dioxygenase (IDO) is a key regulator of immune responses through catalyzing l-tryptophan (l-Trp) oxidation. Here, we show that hydrogen peroxide (H(2)O(2)) activates the peroxidase function of IDO to induce protein oxidation and inhibit dioxygenase activity. Exposure...

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Main Authors: Freewan, Mohammed, Rees, Martin D., Plaza, Tito S. Sempértegui, Glaros, Elias, Lim, Yean J., Wang, Xiao Suo, Yeung, Amanda W. S., Witting, Paul K., Terentis, Andrew C., Thomas, Shane R.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2013
נושאים:
Enzymology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548559/
https://ncbi.nlm.nih.gov/pubmed/23209301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.410993
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