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Crystal structure of human indoleamine 2,3-dioxygenase: Catalytic mechanism of O(2) incorporation by a heme-containing dioxygenase
Human indoleamine 2,3-dioxygenase (IDO) catalyzes the cleavage of the pyrrol ring of l-Trp and incorporates both atoms of a molecule of oxygen (O(2)). Here we report on the x-ray crystal structure of human IDO, complexed with the ligand inhibitor 4-phenylimidazole and cyanide. The overall structure...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413787/ https://ncbi.nlm.nih.gov/pubmed/16477023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508996103 |
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