Conopeptide ρ-TIA Defines a New Allosteric Site on the Extracellular Surface of the α(1B)-Adrenoceptor

The G protein-coupled receptor (GPCR) superfamily is an important drug target that includes over 1000 membrane receptors that functionally couple extracellular stimuli to intracellular effectors. Despite the potential of extracellular surface (ECS) residues in GPCRs to interact with subtype-specific...

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Hlavní autoři: Ragnarsson, Lotten, Wang, Ching-I Anderson, Andersson, Åsa, Fajarningsih, Dewi, Monks, Thea, Brust, Andreas, Rosengren, K. Johan, Lewis, Richard J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548491/
https://ncbi.nlm.nih.gov/pubmed/23184947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.430785
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