Conopeptide ρ-TIA Defines a New Allosteric Site on the Extracellular Surface of the α(1B)-Adrenoceptor

The G protein-coupled receptor (GPCR) superfamily is an important drug target that includes over 1000 membrane receptors that functionally couple extracellular stimuli to intracellular effectors. Despite the potential of extracellular surface (ECS) residues in GPCRs to interact with subtype-specific...

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Bibliographische Detailangaben
Hauptverfasser: Ragnarsson, Lotten, Wang, Ching-I Anderson, Andersson, Åsa, Fajarningsih, Dewi, Monks, Thea, Brust, Andreas, Rosengren, K. Johan, Lewis, Richard J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Membrane Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548491/
https://ncbi.nlm.nih.gov/pubmed/23184947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.430785
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