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Mutations of the Ca(2+)-sensing Stromal Interaction Molecule STIM1 Regulate Ca(2+) Influx by Altered Oligomerization of STIM1 and by Destabilization of the Ca(2+) Channel Orai1
A drop of endoplasmic reticulum Ca(2+) concentration triggers its Ca(2+) ssensor protein stromal interaction molecule 1 (STIM1) to oligomerize and accumulate within endoplasmic reticulum-plasma membrane junctions where it activates Orai1 channels, providing store-operated Ca(2+) entry. To elucidate...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3548475/ https://ncbi.nlm.nih.gov/pubmed/23212906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.417246 |
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