Mutations of the Ca(2+)-sensing Stromal Interaction Molecule STIM1 Regulate Ca(2+) Influx by Altered Oligomerization of STIM1 and by Destabilization of the Ca(2+) Channel Orai1

A drop of endoplasmic reticulum Ca(2+) concentration triggers its Ca(2+) ssensor protein stromal interaction molecule 1 (STIM1) to oligomerize and accumulate within endoplasmic reticulum-plasma membrane junctions where it activates Orai1 channels, providing store-operated Ca(2+) entry. To elucidate...

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Detalhes bibliográficos
Main Authors: Kilch, Tatiana, Alansary, Dalia, Peglow, Martin, Dörr, Kathrin, Rychkov, Grigori, Rieger, Heiko, Peinelt, Christine, Niemeyer, Barbara A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548475/
https://ncbi.nlm.nih.gov/pubmed/23212906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.417246
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