Epidermal Growth Factor Promotes Protein Degradation of Epithelial Protein Lost in Neoplasm (EPLIN), a Putative Metastasis Suppressor, during Epithelial-mesenchymal Transition

Aberrant expression of EGF receptors has been associated with hormone-refractory and metastatic prostate cancer (PCa). However, the molecular mechanism for EGF signaling in promoting PCa metastasis remains elusive. Using experimental models of PCa metastasis, we demonstrated that EGF could induce ro...

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Hauptverfasser: Zhang, Shumin, Wang, Xu, Iqbal, Shareen, Wang, Yanru, Osunkoya, Adeboye O., Chen, Zhengjia, Chen, Zhuo, Shin, Dong M., Yuan, Hongwei, Wang, Yongqiang A., Zhau, Haiyen E., Chung, Leland W. K., Ritenour, Chad, Kucuk, Omer, Wu, Daqing
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548460/
https://ncbi.nlm.nih.gov/pubmed/23188829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438341
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