Epidermal Growth Factor Promotes Protein Degradation of Epithelial Protein Lost in Neoplasm (EPLIN), a Putative Metastasis Suppressor, during Epithelial-mesenchymal Transition

Aberrant expression of EGF receptors has been associated with hormone-refractory and metastatic prostate cancer (PCa). However, the molecular mechanism for EGF signaling in promoting PCa metastasis remains elusive. Using experimental models of PCa metastasis, we demonstrated that EGF could induce ro...

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Hlavní autoři: Zhang, Shumin, Wang, Xu, Iqbal, Shareen, Wang, Yanru, Osunkoya, Adeboye O., Chen, Zhengjia, Chen, Zhuo, Shin, Dong M., Yuan, Hongwei, Wang, Yongqiang A., Zhau, Haiyen E., Chung, Leland W. K., Ritenour, Chad, Kucuk, Omer, Wu, Daqing
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548460/
https://ncbi.nlm.nih.gov/pubmed/23188829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438341
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