Diacylglycerol Kinase δ Modulates Akt Phosphorylation through Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase 2 (PHLPP2)

Discovering proteins that modulate Akt signaling has become a critical task, given the oncogenic role of Akt in a wide variety of cancers. We have discovered a novel diacylglycerol signaling pathway that promotes dephosphorylation of Akt. This pathway is regulated by diacylglycerol kinase δ (DGKδ)....

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Bibliographic Details
Main Authors: Crotty, Tracy M., Nakano, Tomoyuki, Stafforini, Diana M., Topham, Matthew K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548457/
https://ncbi.nlm.nih.gov/pubmed/23184957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.407379
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