Diacylglycerol Kinase δ and Protein Kinase Cα Modulate Epidermal Growth Factor Receptor Abundance and Degradation through Ubiquitin-specific Protease 8

Many human epithelial cancers are characterized by abnormal activation of the epidermal growth factor receptor (EGFR), which is often caused by its excessive expression in tumor cells. The abundance of EGFR is modulated, in part, by its ubiquitination, which targets it for degradation. The component...

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מידע ביבליוגרפי
Main Authors: Cai, Jinjin, Crotty, Tracy M., Reichert, Ethan, Carraway, Kermit L., Stafforini, Diana M., Topham, Matthew K.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
Signal Transduction
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844144/
https://ncbi.nlm.nih.gov/pubmed/20064931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.055731
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