Diacylglycerol Kinase δ and Protein Kinase Cα Modulate Epidermal Growth Factor Receptor Abundance and Degradation through Ubiquitin-specific Protease 8

Many human epithelial cancers are characterized by abnormal activation of the epidermal growth factor receptor (EGFR), which is often caused by its excessive expression in tumor cells. The abundance of EGFR is modulated, in part, by its ubiquitination, which targets it for degradation. The component...

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Bibliographische Detailangaben
Hauptverfasser: Cai, Jinjin, Crotty, Tracy M., Reichert, Ethan, Carraway, Kermit L., Stafforini, Diana M., Topham, Matthew K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844144/
https://ncbi.nlm.nih.gov/pubmed/20064931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.055731
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