Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors

The importance of the trifluoromethyl group in the polypharmacological profile of nilotinib was investigated. Molecular editing of nilotinib led to the design, synthesis and biological evaluation of analogues where the trifluoromethyl group was replaced by a proton, fluorine and a methyl group. Whil...

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Detalhes bibliográficos
Main Authors: Duveau, Damien Y., Hu, Xin, Walsh, Martin J., Shukla, Suneet, Skoumbourdis, Amanda P., Boxer, Matthew B., Ambudkar, Suresh V., Shen, Min, Thomas, Craig J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547291/
https://ncbi.nlm.nih.gov/pubmed/23273517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.11.111
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