Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice

Maternal supplementation with folic acid is known to reduce the incidence of neural tube defects (NTDs) by as much as 70%. Despite the strong clinical link between folate and NTDs, the biochemical mechanisms through which folic acid acts during neural tube development remain undefined. The Mthfd1l g...

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Main Authors: Momb, Jessica, Lewandowski, Jordan P., Bryant, Joshua D., Fitch, Rebecca, Surman, Deborah R., Vokes, Steven A., Appling, Dean R.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545794/
https://ncbi.nlm.nih.gov/pubmed/23267094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211199110
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