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Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase

BACKGROUND: Folate-dependent one-carbon metabolism provides one-carbon units for several biological processes. This pathway is highly compartmentalized in eukaryotes, with the mitochondrial pathway producing formate for use in cytoplasmic processes. The mitochondrial enzyme MTHFD2 has been reported...

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Библиографические подробности
Опубликовано в: :Cancer Metab
Главные авторы: Shin, Minhye, Momb, Jessica, Appling, Dean R.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718140/
https://ncbi.nlm.nih.gov/pubmed/29225823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-017-0173-0
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