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Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase

BACKGROUND: Folate-dependent one-carbon metabolism provides one-carbon units for several biological processes. This pathway is highly compartmentalized in eukaryotes, with the mitochondrial pathway producing formate for use in cytoplasmic processes. The mitochondrial enzyme MTHFD2 has been reported...

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Bibliografiske detaljer
Udgivet i:Cancer Metab
Main Authors: Shin, Minhye, Momb, Jessica, Appling, Dean R.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718140/
https://ncbi.nlm.nih.gov/pubmed/29225823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-017-0173-0
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