Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation

Lipin 1 is a coregulator of DNA-bound transcription factors and a phosphatidic acid (PA) phosphatase (PAP) enzyme that catalyzes a critical step in the synthesis of glycerophospholipids. Lipin 1 is highly expressed in adipocytes, and constitutive loss of lipin 1 blocks adipocyte differentiation; how...

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Hlavní autoři: Mitra, Mayurranjan S., Chen, Zhouji, Ren, Hongmei, Harris, Thurl E., Chambers, Kari T., Hall, Angela M., Nadra, Karim, Klein, Samuel, Chrast, Roman, Su, Xiong, Morris, Andrew J., Finck, Brian N.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545773/
https://ncbi.nlm.nih.gov/pubmed/23267081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213493110
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