Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation

Lipin 1 is a coregulator of DNA-bound transcription factors and a phosphatidic acid (PA) phosphatase (PAP) enzyme that catalyzes a critical step in the synthesis of glycerophospholipids. Lipin 1 is highly expressed in adipocytes, and constitutive loss of lipin 1 blocks adipocyte differentiation; how...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Mitra, Mayurranjan S., Chen, Zhouji, Ren, Hongmei, Harris, Thurl E., Chambers, Kari T., Hall, Angela M., Nadra, Karim, Klein, Samuel, Chrast, Roman, Su, Xiong, Morris, Andrew J., Finck, Brian N.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545773/
https://ncbi.nlm.nih.gov/pubmed/23267081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213493110
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars