Loss of lipin 1–mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice

Lipin 1 regulates glycerolipid homeostasis by acting as a phosphatidic acid phosphohydrolase (PAP) enzyme in the triglyceride-synthesis pathway and by regulating transcription factor activity. Mutations in human lipin 1 are a common cause of recurrent rhabdomyolysis in children. Mice with constituti...

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Detalles Bibliográficos
Publicado en:FASEB J
Main Authors: Schweitzer, George G., Collier, Sara L., Chen, Zhouji, McCommis, Kyle S., Pittman, Sara K., Yoshino, Jun, Matkovich, Scot J., Hsu, Fong-Fu, Chrast, Roman, Eaton, James M., Harris, Thurl E., Weihl, Conrad C., Finck, Brian N.
Formato: Artigo
Idioma:Inglês
Publicado: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355067/
https://ncbi.nlm.nih.gov/pubmed/30028636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800361R
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