Conformational Equilibrium of N-Myristoylated cAMP-Dependent Protein Kinase A by Molecular Dynamics Simulations

The catalytic subunit of protein kinase A (PKA-C) is subject to several post- or co-translational modifications that regulate its activity both spatially and temporally. Among those, N-myristoylation increases the kinase affinity for membranes and might also be implicated in substrate recognition an...

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Hauptverfasser: Cembran, Alessandro, Masterson, Larry R., McClendon, Christopher L., Taylor, Susan S., Gao, Jiali, Veglia, Gianluigi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545707/
https://ncbi.nlm.nih.gov/pubmed/23205665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301279f
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