Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease

Sickle cell disease (SCD) is a globally distributed hereditary red blood cell (RBC) disorder. One of the hallmarks of SCD is the presence of circulating dense RBCs, which are important in SCD-related clinical manifestations. In human dense sickle cells, we found reduced calpastatin activity and prot...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: De Franceschi, Lucia, Franco, Robert S., Bertoldi, Mariarita, Brugnara, Carlo, Matté, Alessandro, Siciliano, Angela, Wieschhaus, Adam J., Chishti, Athar H., Joiner, Clinton H.
التنسيق: Artigo
اللغة:Inglês
منشور في: Federation of American Societies for Experimental Biology 2013
الموضوعات:
Research Communications
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545531/
https://ncbi.nlm.nih.gov/pubmed/23085996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-217836
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