Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.

Excessive red cell dehydration contributes to the pathophysiology of sickle cell disease (SCD). The densest fraction of sickle red cells (with the highest corpuscular hemoglobin concentration) undergoes the most rapid polymerization of deoxy-hemoglobin S, leading to accelerated cell sickling and inc...

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Publicado no:Blood Cells Mol Dis
Main Authors: Shmukler, Boris E., Rivera, Alicia, Bhargava, Parul, Nishimura, Katherine, Hsu, Ann, Kim, Edward H., Trudel, Marie, Rust, Marco B., Hubner, Christian A., Brugnara, Carlo, Alper, Seth L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744291/
https://ncbi.nlm.nih.gov/pubmed/31352162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2019.102346
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