The Combination of Inhibitors of FGF/MEK/Erk and GSK3β Signaling Increases the Number of OCT3/4- and NANOG-Positive Cells in the Human Inner Cell Mass, But Does Not Improve Stem Cell Derivation

In embryonic stem cell culture, small molecules can be used to alter key signaling pathways to promote self-renewal and inhibit differentiation. In mice, small-molecule inhibition of both the FGF/MEK/Erk and the GSK3β pathways during preimplantation development suppresses hypoblast formation, and th...

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Bibliographische Detailangaben
Hauptverfasser: Van der Jeught, Margot, O'Leary, Thomas, Ghimire, Sabitri, Lierman, Sylvie, Duggal, Galbha, Versieren, Karen, Deforce, Dieter, Chuva de Sousa Lopes, Susana, Heindryckx, Björn, De Sutter, Petra
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2013
Schlagworte:
Original Research Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545355/
https://ncbi.nlm.nih.gov/pubmed/22784186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2012.0256
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