The Combination of Inhibitors of FGF/MEK/Erk and GSK3β Signaling Increases the Number of OCT3/4- and NANOG-Positive Cells in the Human Inner Cell Mass, But Does Not Improve Stem Cell Derivation

In embryonic stem cell culture, small molecules can be used to alter key signaling pathways to promote self-renewal and inhibit differentiation. In mice, small-molecule inhibition of both the FGF/MEK/Erk and the GSK3β pathways during preimplantation development suppresses hypoblast formation, and th...

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Detalhes bibliográficos
Main Authors: Van der Jeught, Margot, O'Leary, Thomas, Ghimire, Sabitri, Lierman, Sylvie, Duggal, Galbha, Versieren, Karen, Deforce, Dieter, Chuva de Sousa Lopes, Susana, Heindryckx, Björn, De Sutter, Petra
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Original Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545355/
https://ncbi.nlm.nih.gov/pubmed/22784186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2012.0256
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