The Cystine/Glutamate Antiporter System x(c)(−) in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

The antiporter system x(c)(−) imports the amino acid cystine, the oxidized form of cysteine, into cells with a 1:1 counter-transport of glutamate. It is composed of a light chain, xCT, and a heavy chain, 4F2 heavy chain (4F2hc), and, thus, belongs to the family of heterodimeric amino acid transporte...

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Autors principals: Lewerenz, Jan, Hewett, Sandra J., Huang, Ying, Lambros, Maria, Gout, Peter W., Kalivas, Peter W., Massie, Ann, Smolders, Ilse, Methner, Axel, Pergande, Mathias, Smith, Sylvia B., Ganapathy, Vadivel, Maher, Pamela
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2013
Matèries:
Comprehensive Invited Reviews
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545354/
https://ncbi.nlm.nih.gov/pubmed/22667998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4391
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