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The Cystine/Glutamate Antiporter System x(c)(−) in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities
The antiporter system x(c)(−) imports the amino acid cystine, the oxidized form of cysteine, into cells with a 1:1 counter-transport of glutamate. It is composed of a light chain, xCT, and a heavy chain, 4F2 heavy chain (4F2hc), and, thus, belongs to the family of heterodimeric amino acid transporte...
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Main Authors: | , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Mary Ann Liebert, Inc.
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3545354/ https://ncbi.nlm.nih.gov/pubmed/22667998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4391 |
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