Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation

High affinity antibodies are generated in mice and humans by means of somatic hypermutation (SHM) of variable (V) regions of Ig genes. Mutations with rates of 10(−5)–10(−3) per base pair per generation, about 10(6)-fold above normal, are targeted primarily at V-region hot spots by unknown mechanisms...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Poltoratsky, Vladimir, Woo, Caroline J., Tippin, Brigette, Martin, Alberto, Goodman, Myron F., Scharff, Matthew D.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2001
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC35453/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11427727/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.141222198
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