Interpretable deep learning reveals the role of an E-box motif in suppressing somatic hypermutation of AGCT motifs within human immunoglobulin variable regions

IntroductionSomatic hypermutation (SHM) of immunoglobulin variable (V) regions by activation induced deaminase (AID) is essential for robust, long-term humoral immunity against pathogen and vaccine antigens. AID mutates cytosines preferentially within WRCH motifs (where W=A or T, R=A or G and H=A, C...

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Үндсэн зохиолчид:	Abhik Tambe, Thomas MacCarthy, Rushad Pavri
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2024-05-01
Цуврал:	Frontiers in Immunology
Нөхцлүүд:	somatic hypermutation (SHM) activation induced deaminase (AID) immunoglobulin heavy chain deep learning integrated gradients E-box transcription factors
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1407470/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!