Expression of Constitutive Fusion of Ubiquitin to PCNA Restores the Level of Immunoglobulin A/T Mutations During Somatic Hypermutation in the Ramos Cell Line

Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is a B cell specific process required for the generation of specific and high affinity antibodies during the maturation of the immune response against foreign antigens. This process depends on the activity of both activation-induced cytidine d...

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Bibliografische gegevens

Hoofdauteurs:	Leticia K. Lerner, Dorine Bonte, Morwenna Le Guillou, Mahwish Mian Mohammad, Zeinab Kasraian, Alain Sarasin, Emmanuelle Despras, Said Aoufouchi
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Frontiers Media S.A. 2022-04-01
Reeks:	Frontiers in Immunology
Onderwerpen:	immunoglobulin somatic hypermutation PCNA monoubiquitination Ramos B cell line USP1 inhibition A/T mutation pathway
Online toegang:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.871766/full
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