Expression of Constitutive Fusion of Ubiquitin to PCNA Restores the Level of Immunoglobulin A/T Mutations During Somatic Hypermutation in the Ramos Cell Line

Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is a B cell specific process required for the generation of specific and high affinity antibodies during the maturation of the immune response against foreign antigens. This process depends on the activity of both activation-induced cytidine d...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Leticia K. Lerner, Dorine Bonte, Morwenna Le Guillou, Mahwish Mian Mohammad, Zeinab Kasraian, Alain Sarasin, Emmanuelle Despras, Said Aoufouchi
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2022-04-01
Serija:	Frontiers in Immunology
Teme:	immunoglobulin somatic hypermutation PCNA monoubiquitination Ramos B cell line USP1 inhibition A/T mutation pathway
Online dostop:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.871766/full
Oznake:	Označite Brez oznak, prvi označite!