Discontiguous recurrences of IDH-wildtype glioblastoma share a common origin with the initial tumor and are frequently hypermutated

Abstract Glioblastoma is the deadliest primary brain tumor, largely due to inevitable recurrence of the disease after treatment. While most recurrences are local, patients rarely present with a new discontiguous focus of glioblastoma. Little is currently known about the genetic profile of discontigu...

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Autori principali:	Malcolm F. McDonald, Sricharan Gopakumar, Tareq A. Juratli, Ilker Y. Eyüpoglu, Ganesh Rao, Jacob J. Mandel, Ali Jalali
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-01-01
Serie:	Acta Neuropathologica Communications
Soggetti:	IDH WT glioma Glioblastoma recurrence Multicentric Discontiguous Hypermutation
Accesso online:	https://doi.org/10.1186/s40478-024-01900-1
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