mIDH-associated DNA hypermethylation in acute myeloid leukemia reflects differentiation blockage rather than inhibition of TET-mediated demethylation

Isocitrate dehydrogenases 1 and 2 (IDH1/2) are recurrently mutated in acute myeloid leukemia (AML), but their mechanistic role in leukemogenesis is poorly understood. The inhibition of TET enzymes by D-2-hydroxyglutarate (D-2-HG), which is produced by mutant IDH1/2 (mIDH1/2), has been suggested to p...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Laura Wiehle, Günter Raddatz, Stefan Pusch, Julian Gutekunst, Andreas von Deimling, Manuel Rodríguez-Paredes, Frank Lyko
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Shared Science Publishers OG 2017-09-01
Цуврал:	Cell Stress
Нөхцлүүд:	mIDH DNA methylation AML TET enzymes differentiation D-2-hydroxyglutarate
Онлайн хандалт:	http://www.cell-stress.com/researcharticles/midh-associated-dna-hypermethylation-in-acute-myeloid-leukemia-reflects-differentiation-blockage-rather-than-inhibition-of-tet-mediated-demethylation/
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