Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation

High affinity antibodies are generated in mice and humans by means of somatic hypermutation (SHM) of variable (V) regions of Ig genes. Mutations with rates of 10(−5)–10(−3) per base pair per generation, about 10(6)-fold above normal, are targeted primarily at V-region hot spots by unknown mechanisms...

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Argitaratua izan da:	Proc Natl Acad Sci U S A
Egile Nagusiak:	Poltoratsky, Vladimir, Woo, Caroline J., Tippin, Brigette, Martin, Alberto, Goodman, Myron F., Scharff, Matthew D.
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	National Academy of Sciences 2001
Gaiak:	Biological Sciences
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC35453/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11427727/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.141222198
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