Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification

Uracil arises in cellular DNA by cytosine (C) deamination and erroneous replicative incorporation of deoxyuridine monophosphate opposite adenine. The former generates C → thymine transition mutations if uracil is not removed by uracil-DNA glycosylase (UDG) and replaced by C by the base excision repa...

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Библиографические подробности

Главные авторы:	Marina Alexeeva, Marivi Nabong Moen, Xiang Ming Xu, Anette Rasmussen, Ingar Leiros, Finn Kirpekar, Arne Klungland, Lene Alsøe, Hilde Nilsen, Svein Bjelland
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2021-12-01
Серии:	Frontiers in Immunology
Предметы:	human UNG class switch recombination somatic hypermutation immunoglobulin diversification cytosine deamination
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.762032/full
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