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Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification

Uracil arises in cellular DNA by cytosine (C) deamination and erroneous replicative incorporation of deoxyuridine monophosphate opposite adenine. The former generates C → thymine transition mutations if uracil is not removed by uracil-DNA glycosylase (UDG) and replaced by C by the base excision repa...

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Uloženo v:
Hlavní autoři: Marina Alexeeva, Marivi Nabong Moen, Xiang Ming Xu, Anette Rasmussen, Ingar Leiros, Finn Kirpekar, Arne Klungland, Lene Alsøe, Hilde Nilsen, Svein Bjelland
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021-12-01
Edice:Frontiers in Immunology
Témata:
human UNG
class switch recombination
somatic hypermutation
immunoglobulin diversification
cytosine deamination
On-line přístup:https://www.frontiersin.org/articles/10.3389/fimmu.2021.762032/full
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