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Molecular Docking and NMR Binding Studies to Identify Novel Inhibitors of Human Phosphomevalonate Kinase
Phosphomevalonate kinase (PMK) phosphorylates mevalonate-5-phosphate (M5P) in the mevalonate pathway, which is the sole source of isoprenoids and steroids in humans. We have identified new PMK inhibitors with virtual screening, using Autodock. Promising hits were verified and their affinity measured...
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Main Authors: | , , , , , , , |
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格式: | Artigo |
語言: | Inglês |
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2012
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在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3544975/ https://ncbi.nlm.nih.gov/pubmed/23146631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.10.130 |
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