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Solution Structures of Mycobacterium tuberculosis Thioredoxin C and Models of the Intact Thioredoxin System Suggest New Approaches to Inhibitor and Drug Design

Here we report the NMR solution structures of Mycobacterium tuberculosis (M. tuberculosis) thioredoxin C in both oxidized and reduced states, with discussion of structural changes that occur in going between redox states. The NMR solution structure of the oxidized TrxC corresponds closely to that of...

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Detalhes bibliográficos
Main Authors: Olson, Andrew L., Neumann, Terrence S., Cai, Sheng, Sem, Daniel S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620657/
https://ncbi.nlm.nih.gov/pubmed/23229911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24228
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