B cell-TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in SLE-prone mice

Systemic Lupus Erythematosus (SLE) is a chronic systemic autoimmune disease characterized by the production of anti-nuclear autoantibodies (ANA). ANA development is recognized as one of the initial stages of disease which often results in systemic inflammation, kidney disease and death. The etiology...

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Detalhes bibliográficos
Main Authors: Hwang, Sun-Hee, Lee, Huiyin, Yamamoto, Miwako, Jones, Leigh A, Dayalan, Jivanaah, Hopkins, Richard, Zhou, Xin J, Yarovinsky, Felix, Connolly, John E, de Lafaille, Maria A Curotto, Wakeland, Edward K., Fairhurst, Anna-Marie
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544945/
https://ncbi.nlm.nih.gov/pubmed/23150717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202195
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