High TLR7 Expression Drives the Expansion of CD19(+)CD24(hi)CD38(hi) Transitional B Cells and Autoantibody Production in SLE Patients

Signaling through Toll-like receptor 7 (TLR7) drives the production of type I IFN and promotes the activation of autoreactive B cells and is implicated in the pathogenesis of systemic lupus erythematosus (SLE). While TLR7 has been extensively studied in murine lupus, much less is known about its rol...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Wang, Ting, Marken, John, Chen, Janice, Tran, Van Bao, Li, Quan-Zhen, Li, Mengtao, Cerosaletti, Karen, Elkon, Keith B., Zeng, Xiaofeng, Giltiay, Natalia V.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559307/
https://ncbi.nlm.nih.gov/pubmed/31231380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01243
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