High TLR7 Expression Drives the Expansion of CD19(+)CD24(hi)CD38(hi) Transitional B Cells and Autoantibody Production in SLE Patients

Signaling through Toll-like receptor 7 (TLR7) drives the production of type I IFN and promotes the activation of autoreactive B cells and is implicated in the pathogenesis of systemic lupus erythematosus (SLE). While TLR7 has been extensively studied in murine lupus, much less is known about its rol...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Immunol
Prif Awduron: Wang, Ting, Marken, John, Chen, Janice, Tran, Van Bao, Li, Quan-Zhen, Li, Mengtao, Cerosaletti, Karen, Elkon, Keith B., Zeng, Xiaofeng, Giltiay, Natalia V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2019
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559307/
https://ncbi.nlm.nih.gov/pubmed/31231380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01243
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg