Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

BACKGROUND: Macroautophagy is an evolutionarily conserved mechanism for bulk intracellular degradation of proteins and organelles. Pathological studies have implicated macroautophagy defects in human neurodegenerative disorders of aging including Alzheimer’s disease and tauopathies. Neuronal deficie...

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Main Authors: Inoue, Keiichi, Rispoli, Joanne, Kaphzan, Hanoch, Klann, Eric, Chen, Emily I, Kim, Jongpil, Komatsu, Masaaki, Abeliovich, Asa
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544596/
https://ncbi.nlm.nih.gov/pubmed/22998728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-48
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