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On the efficiency of nonparametric variance estimation in sequential dose-finding
Dose-finding in clinical studies is typically formulated as a quantile estimation problem, for which a correct specification of the variance function of the outcomes is important. This is especially true for sequential study where the variance assumption directly involves in the generation of the de...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3544527/ https://ncbi.nlm.nih.gov/pubmed/23329867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jspi.2012.08.014 |
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