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Stochastic approximation with virtual observations for dose-finding on discrete levels
Phase I clinical studies are experiments in which a new drug is administered to humans to determine the maximum dose that causes toxicity with a target probability. Phase I dose-finding is often formulated as a quantile estimation problem. For studies with a biological endpoint, it is common to defi...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3412600/ https://ncbi.nlm.nih.gov/pubmed/23049118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biomet/asp065 |
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